Charles Leighton (24 June 1921 – 26 June 2009) was an American classical and jazz harmonica player who performed from the mid-1940s to the mid-1950s. After a hiatus while he managed a recording studio, he performed again in the 1980s until his death. He performed as a soloist and as a member of international ensembles. He worked as a studio musician for radio, film, and television.