About: Bile acid:sodium symporter

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About: Bile acid:sodium symporter Goto Sponge NotDistinct Permalink

An Entity of Type : dbo:Protein, within Data Space : dbpedia.org associated with source document(s)
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http://dbpedia.org/describe/?url=http%3A%2F%2Fdbpedia.org%2Fresource%2FBile_acid%3Asodium_symporter&graph=http%3A%2F%2Fdbpedia.org&graph=http%3A%2F%2Fdbpedia.org

This family of proteins are found both in prokaryotes and eukaryotes. In mammals, they are transmembrane proteins with functions in the liver and in the intestine. They are members of the solute carrier family of cotransporter genes which include SLC10A1 and SLC10A2.

Attributes	Values
rdf:type	Thing Biomolecule Biomolecule Protein protein
rdfs:label	Bile acid:sodium symporter (en)
rdfs:comment	This family of proteins are found both in prokaryotes and eukaryotes. In mammals, they are transmembrane proteins with functions in the liver and in the intestine. They are members of the solute carrier family of cotransporter genes which include SLC10A1 and SLC10A2. (en)
name	SBF (en)
dcterms:subject	Protein families Transmembrane transporters
Wikipage page ID	35051968 (xsd:integer)
Wikipage revision ID	1039975418 (xsd:integer)
Link from a Wikipage to another Wikipage	Prokaryotes Enterohepatic circulation Small intestine SLC10A1 Protein families SLC10A2 Co-transport Elobixibat Constipation Transmembrane proteins Liver Transmembrane transporters Irritable bowel syndrome Eukaryotes Basolateral membrane Protein family Hepatitis B Cotransporter Solute carrier family Bile acid Circulatory system Hepatitis D Ileum Brush border Intestine NTCP
sameAs	Bile acid:sodium symporter Bile acid:sodium symporter Bile acid:sodium symporter
TCDB	2 (xsd:integer)
dbp:wikiPageUsesTemplate	dbt:Infobox_protein_family dbt:InterPro_content dbt:Reflist
InterPro	IPR002657 (en)
Pfam	PF01758 (en)
Pfam clan	CL0064 (en)
symbol	SBF (en)
has abstract	This family of proteins are found both in prokaryotes and eukaryotes. In mammals, they are transmembrane proteins with functions in the liver and in the intestine. They are members of the solute carrier family of cotransporter genes which include SLC10A1 and SLC10A2. SLC10A1 encodes the sodium-taurocholate cotransporting polypeptide (NTCP) expressed in the liver and found on the basolateral membranes. It is involved in the uptake of all types of bile acids from portal blood plasma, a process mediated by the co-transport of Na+. It is also capable of transporting other solutes and is necessary for the entry of hepatitis B and hepatitis D viruses into the hepatocyte. SLC10A2 encodes the apical sodium bile acid transporter (ASBT) expressed in the small intestine with highest concentrations in the ileum. It is found on the brush border membrane and is also known as the ileal bile acid transporter (IBAT). It is responsible for the initial uptake of bile acids from the intestine as part of the enterohepatic circulation. Inhibition of the intestinal bile acid:sodium cotransporter by elobixibat is under development for the treatment of constipation and irritable bowel syndrome. (en)
OPM family	224 (xsd:integer)
OPM protein	3 (xsd:integer)
prov:wasDerivedFrom	wikipedia-en:Bile_acid:sodium_symporter?oldid=1039975418&ns=0
page length (characters) of wiki page	3535 (xsd:nonNegativeInteger)
Symbol	SBF
foaf:isPrimaryTopicOf	wikipedia-en:Bile_acid:sodium_symporter
is Link from a Wikipage to another Wikipage of	Elobixibat Sodium/bile acid cotransporter Ileal sodium/bile acid cotransporter Transporter Classification Database
is foaf:primaryTopic of	wikipedia-en:Bile_acid:sodium_symporter

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