About: Benzhydrocodone     Goto   Sponge   NotDistinct   Permalink

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Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule. It is designed to be an opioid analgesic with a low chance of recreational use.

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rdfs:label
  • Benzhydrocodone (en)
rdfs:comment
  • Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule. It is designed to be an opioid analgesic with a low chance of recreational use. (en)
foaf:depiction
  • http://commons.wikimedia.org/wiki/Special:FilePath/Benzhydrocodone.svg
  • http://commons.wikimedia.org/wiki/Special:FilePath/Benzhydrocodone_molecule_ball.png
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CAS number
ChEMBL
ChemSpiderID
DrugBank
  • DB15465 (en)
H
image
  • Benzhydrocodone molecule ball.png (en)
IUPAC name
KEGG
  • D10612 (en)
n
O
PubChem
routes of administration
SMILES
  • CN1CC[C@]23c4c5cccOC (en)
StdInChI
StdInChIKey
  • VPMRSLWWUXNYRY-PJCFOSJUSA-N (en)
synonyms
  • KP201 (en)
UNII
has abstract
  • Benzhydrocodone (INN) (contracted from benzoate-hydrocodone) is an opioid prodrug of the morphinan class. Its chemical structure consists of hydrocodone coupled with benzoic acid. Benzhydrocodone itself is inactive and acts as a prodrug to hydrocodone upon cleavage of the benzoate portion of the molecule. It is designed to be an opioid analgesic with a low chance of recreational use. Created by Kempharm, Inc., a biopharmaceutical company in Coralville, Iowa, President and CEO, Travis Mickle, believes the molecular-based approach to abuse deterrent may be more effective than many formulation-based approaches. When approved, Apadaz received a labeling that highlighted all relevant aspects of the drug, including the lower abuse profile compared to traditional hydrocodone-acetaminophen. The labeling showed several items supporting a lower abuse profile than traditional hydrocodone-acetaminophen; namely, a lower Drug Liking in the first two hours after intranasal abuse (snorting), and the conversion of benzhydrocodone to hydrocodone in vitro being a "difficult process" -- with benzhydrocodone being a more difficult drug to abuse according to FDA Apadaz adcom documents. (en)
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page length (characters) of wiki page
CAS number
  • 1259440-61-3
ChEMBL
  • 3137321
DrugBank
  • DB15465
FDA UNII code
  • 75MS0AAZ9I
KEGG
  • D10612
PubChem
  • 49836084
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