Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. The first aurora kinases were identified in Drosophila melanogaster, where mutations led to failure of centrosome separation with the monopolar spindles reminiscent of the North Pole, suggesting the name aurora.
| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:label
| - أورورا كايناز (ar)
- Aurorakinasen (de)
- Aurora kinase (en)
- Aurora kinasi (it)
|
| rdfs:comment
| - Aurorakinasen sind Enzyme aus der Familie der Serin/Threonin-Proteinkinasen. Sie spielen beim Zellwachstum eine wichtige Rolle. In der Onkologie sind die Aurorakinasen potentielle Targets für die Entwicklung neuer Arzneistoffe zur Therapie von Krebserkrankungen. Die für die Enzyme codierenden Gene werden zu den Onkogenen gerechnet. (de)
- كايناز أورورا (Aurora kinases) وهي انزيمات والتي تعتبر من كاينازات السيرين / والثريونين والتي تعتبر ضرورية في عملية تكاثر الخلايا. ويساعد هذا الإنزيم الخلية المنقسمة على توزيع موادها الوراثية على الخلايا الجديدة. وبشكل أكثر تحديدًا ، تلعب كايناز أورورا Aurora kinases دورًا حاسمًا في الانقسام الخلوي من خلال التحكم في الفصل الكروماتيدي. ويمكن أن تؤدي العيوب في هذا الفصل إلى عدم الاستقرار الوراثي ، وهي حالة ترتبط ارتباطًا كبيرًا بحدوث الأورام [1]. (ar)
- Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. The first aurora kinases were identified in Drosophila melanogaster, where mutations led to failure of centrosome separation with the monopolar spindles reminiscent of the North Pole, suggesting the name aurora. (en)
- Le chinasi Aurora (serina/treonina kinasi o Aurora/Ipl1p-related kinase (AIRK)) sono delle chinasi della serina e treonina.Esse sono essenziali per la duplicazione delle cellule, infatti l'enzima aiuta la separazione di materiali genetici cellulari per produrre le cellule figlie. Le chinasi Aurora giocano un ruolo critico nella divisione cellulare controllando la segregazione cromatidica. Le alterazioni di questa segregazione per instabilità genetica sono una condizione che è altamente associata con lo sviluppo di tumori (tumorigenesi). (it)
|
| dcterms:subject
| |
| Wikipage page ID
| |
| Wikipage revision ID
| |
| Link from a Wikipage to another Wikipage
| |
| sameAs
| |
| dbp:wikiPageUsesTemplate
| |
| has abstract
| - كايناز أورورا (Aurora kinases) وهي انزيمات والتي تعتبر من كاينازات السيرين / والثريونين والتي تعتبر ضرورية في عملية تكاثر الخلايا. ويساعد هذا الإنزيم الخلية المنقسمة على توزيع موادها الوراثية على الخلايا الجديدة. وبشكل أكثر تحديدًا ، تلعب كايناز أورورا Aurora kinases دورًا حاسمًا في الانقسام الخلوي من خلال التحكم في الفصل الكروماتيدي. ويمكن أن تؤدي العيوب في هذا الفصل إلى عدم الاستقرار الوراثي ، وهي حالة ترتبط ارتباطًا كبيرًا بحدوث الأورام [1]. تم التعرف على ثلاثة أنواع من كاينازات أورورا في خلايا الثدييات حتى الآن. إلى جانب كون هذه الإنزيمات مهمة في عملية انقسام الخلايا، ولهذه الكاينازات الثلاثة اهتمامًا كبيرًا في مجال أبحاث السرطان نظرًا لظهور تركيزها المرتفع في العديد من أنواع السرطان البشري[2]. يحتوي كيناز أورورا البشري على N-terminal مكونة من بداية طولها 39–129، ونهاية قصيرة C-terminal تحتوي على 15-20. تساهم البداية لثلاثة بروتينات N-terminal في الحفاظ على تسلسل الأحماض الأمينية للبروتين ، والذي يحدد الانتقائية خلال تفاعلات البروتين-البروتين [1]. (ar)
- Aurorakinasen sind Enzyme aus der Familie der Serin/Threonin-Proteinkinasen. Sie spielen beim Zellwachstum eine wichtige Rolle. In der Onkologie sind die Aurorakinasen potentielle Targets für die Entwicklung neuer Arzneistoffe zur Therapie von Krebserkrankungen. Die für die Enzyme codierenden Gene werden zu den Onkogenen gerechnet. (de)
- Aurora kinases are serine/threonine kinases that are essential for cell proliferation. They are phosphotransferase enzymes that help the dividing cell dispense its genetic materials to its daughter cells. More specifically, Aurora kinases play a crucial role in cellular division by controlling chromatid segregation. Defects in this segregation can cause genetic instability, a condition which is highly associated with tumorigenesis. The first aurora kinases were identified in Drosophila melanogaster, where mutations led to failure of centrosome separation with the monopolar spindles reminiscent of the North Pole, suggesting the name aurora. Three Aurora kinases have been identified in mammalian cells to date. Besides being implicated as mitotic regulators, these three kinases have generated significant interest in the cancer research field due to their elevated expression profiles in many human cancers. The human Aurora kinases present a similar domain organization, with a N-terminal domain of 39–129 residues in length, a related Ser/Thr protein kinase domain and a short C-terminal domain containing 15–20 residues. The N-terminal domain of three proteins share low sequence conservation, which determines selectivity during protein–protein interactions. (en)
- Le chinasi Aurora (serina/treonina kinasi o Aurora/Ipl1p-related kinase (AIRK)) sono delle chinasi della serina e treonina.Esse sono essenziali per la duplicazione delle cellule, infatti l'enzima aiuta la separazione di materiali genetici cellulari per produrre le cellule figlie. Le chinasi Aurora giocano un ruolo critico nella divisione cellulare controllando la segregazione cromatidica. Le alterazioni di questa segregazione per instabilità genetica sono una condizione che è altamente associata con lo sviluppo di tumori (tumorigenesi). Sono tre le chinasi che hanno creato un notevole interesse per la ricerca sul cancro poiché i loro profili di espressione sono elevati in molti tumori umani.Inoltre, i polimorfismi del gene della aurora chinasi sono associati ad un aumento del rischio o ad esordio precoce del cancro. Sono chiamati enzimi Aurora perché i fusi mitotici sparsi, presenti nelle forme mutanti, somigliano all'Aurora boreale. (it)
|
| gold:hypernym
| |
| prov:wasDerivedFrom
| |
| page length (characters) of wiki page
| |
| foaf:isPrimaryTopicOf
| |
| is Link from a Wikipage to another Wikipage
of | |
| is Wikipage redirect
of | |
| is Wikipage disambiguates
of | |
| is foaf:primaryTopic
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)