Anna Manning Comfort, M.D. (née Manning; January 19, 1845 – January 12, 1931) was an American physician who specialized in women's diseases. She was the first woman medical graduate to practice in the state of Connecticut. Comfort opposed U.S. imperialism. She was one of the pioneer leaders in the cause of woman suffrage, as well as a social reformer who defended the rights of Native Americans and African Americans. A member of Sorosis since 1878, Comfort was also a pioneer clubwoman.