State Route 52 (SR 52) is an 82.805-mile-long (133.262 km) state highway in the southeastern part of the U.S. state of Alabama. The western terminus of the highway is at an intersection with U.S. Route 331 (US 331) at Opp. The eastern terminus of the highway is at the Georgia state line east of Columbia, where the highway crosses over the Chattahoochee River and enter Hilton, Georgia as Georgia State Route 62 (SR 62).