This article documents expected notable spaceflight events during the year 2025. In 2025, NASA's Artemis Program is expected to launch the Artemis III mission, which will land astronauts near the south pole of the Moon. It is expected to be the first mission to land humans on the Moon since 1972. The first uncrewed flight of Orel, Russia's replacement for the crewed Soyuz spacecraft, is scheduled for 2025. Russia also plans to launch the Spektr-UV (World Space Observatory-Ultraviolet), a space telescope that will be developed by multiple nations.