The 2022 Rice Owls football team represents Rice University as a member of Conference USA (C-USA) during the 2022 NCAA Division I FBS football season. They will be led by head coach Mike Bloomgren, who will be coaching his fifth season with the team. The Owls will play their home games at the Rice Stadium in Houston, Texas. During last season, on October 21, 2021, Rice accepted the invitation to join the American Athletic Conference (AAC) and will become a full-member on July 1, 2023. The 2022 season is expected to be the program's last season as a member of Conference USA.