The 2022 División Intermedia season, named "Homenaje al Doctor Luis Lezcano Pastore y al Escribano Julio César Ortiz Duarte", was the 104th season of the second-tier league of Paraguayan football and 25th under the Paraguayan División Intermedia name. The season began on 1 April and ended on 11 October 2022. The fixtures for the season were announced on 15 December 2021.