The 2022 Challenge Cup, known for sponsorship reasons as the 2022 Betfred Challenge Cup, was the 121st edition of the Challenge Cup, the main rugby league knockout cup tournament in British rugby league run by the Rugby Football League (RFL). It started on 15 January 2022 and ended, with the final at Tottenham Hotspur Stadium on 28 May. St Helens were the defending champions going into 2022, but they were eliminated in the semi final by Wigan Warriors, who went on to win the Final, by narrowly defeating Huddersfield Giants 16-14.