The 2021 St. Thomas Tommies football team represented the University of St. Thomas in Saint Paul, Minnesota as a member of the Pioneer Football League (PFL) during the 2021 NCAA Division I FCS football season. Led by 13th-year head coach Glenn Caruso, the Tommies compiled an overall record of 7–3 with a mark of 6–2 in conference play, tying for third place in the PFL. St. Thomas played home games at O'Shaughnessy Stadium in Saint Paul, Minnesota.