The 2021 Pit Boss 250 was a NASCAR Xfinity Series race held on May 22, 2021. It was contested over 46 laps on the 3.410-mile (5.488 km) road course. It was the tenth race of the 2021 NASCAR Xfinity Series season. Joe Gibbs Racing driver Kyle Busch, collected his first win of the season, and his 98th of his career.