The 2021 División Profesional season (officially the Copa de Primera TIGO-Visión Banco 2021 for sponsorship reasons) was the 87th season of the Paraguayan Primera División, the top-flight professional football league in Paraguay. The season began on 5 February and ended on 5 December 2021. The fixtures for the season were announced on 15 January 2021. Olimpia were the defending champions after winning the 2020 Clausura tournament.