The Super Regional round of the 2021 NCAA Division I Baseball Tournament were eight best-of-three-games series to determine the participating teams of the 2021 College World Series. These matchups were: The higher seeded team of each series hosted all three games. The higher seed team was designated as the home team in Games 1 and (if necessary) 3, while the lower seeded team was the designated home team in Game 2. The only exception this year was the series between Dallas Baptist and Virginia, which was held at Founders Park in Columbia, South Carolina.