The 2021 Conference USA women's soccer tournament was the postseason women's soccer tournament for Conference USA held from November 1 through November 7, 2021. The nine-match tournament took place at FAU Soccer Stadium in Boca Raton, Florida. The ten-team single-elimination tournament consisted of four rounds based on seeding from regular season conference play. The defending champions were the Rice Owls. Rice was unable to defended their title after being defeated by Middle Tennessee in the Quarterfinals. The Old Dominion Monarchs won the title by defeating Southern Miss in the final 1–0. The conference championship was the first for the Old Dominion women's soccer program and first for head coach Angie Hind. As tournament champions, Old Dominion earned C-USA's automatic berth into the 2