The 2021 Colombian Women's Football League (officially known as the Liga Femenina BetPlay Dimayor 2021 for sponsorship purposes) was the fifth season of Colombia's top-flight women's football league. The season started on 10 July and ended on 12 September 2021. Deportivo Cali won their first title in the competition, defeating the defending champions Santa Fe in the double-legged final series by a 6–3 aggregate score.