The 2021–22 Vanderbilt Commodores men's basketball team represented Vanderbilt University during the 2021–22 NCAA Division I men's basketball season. The team was led by third-year head coach Jerry Stackhouse, and played their home games at Memorial Gymnasium in Nashville, Tennessee as a member of the Southeastern Conference. They finished the season 19–16, 7–11 in SEC Play to finish in eleventh place. They defeated Georgia and Alabama to advance to the quarterfinals of the SEC tournament where they lost to Kentucky. They received an at-large bid to the National Invitation Tournament where they defeated Belmont and Dayton to advance to the quarterfinals where they lost to Xavier.