The 2021–22 Santosh Trophy is the 75th edition of the Santosh Trophy, the premier competition in India for teams representing their regional and state football associations. The last season was cancelled due to COVID-19 pandemic in India. The main round of the tournament was held in Malappuram, and was contested by 10 teams divided into two groups. Kerala and West Bengal from Group A and Manipur and Karnataka from Group B reached the semi-finals, and eventually Kerala and West Bengal faced in the . Kerala won their seventh title after defeating West Bengal in the penalties.