The 2021–22 LSU Tigers basketball team represented Louisiana State University during the 2021–22 NCAA Division I men's basketball season. The team's head coach was Will Wade, in his fifth (and final) season at LSU. They played their home games at the Pete Maravich Assembly Center in Baton Rouge, Louisiana, as a member of the Southeastern Conference. They finished the season 22–12, 9–9 in SEC Play to finish a five-way tie for fifth place. As the No. 5 seed in the SEC tournament, they defeated Missouri in the Second Round, before losing in the quarterfinals to Arkansas. They received an at-large bid to the NCAA tournament as the No. 6 seed in the Midwest Region, where they were upset in the First Round by Iowa State.