The 2021–22 Botola Pro, also known as Botola Pro Inwi for sponsorship reasons, is the 65th season of the Premier League and the 11th under its new format of Moroccan Pro League, the top Moroccan professional league for association football clubs, since its establishment in 1956. Wydad Casablanca came into the season as defending champions of the 2020–21 season. Olympique Khouribga and Jeunesse Soualem entered as the two promoted teams from the 2020–21 Botola 2. The season began in September, 10th 2021 and ended in July, 5th 2022.