The 2021–22 Arizona Wildcats women's basketball team represented the University of Arizona during the 2021–22 NCAA Division I women's basketball season. The Wildcats were led by sixth-year head coach Adia Barnes. This was the Wildcats' 48th season at the on-campus McKale Center in Tucson, Arizona and 43rd season as a member of the Pac-12 Conference. They finished with a record of 21–8, 10–6 in Pac-12 play. The Wildcats were invited to the 2022 NCAA tournament where they defeated UNLV in the First Round before losing to North Carolina in the Second Round.