The 2021–22 season was ŠK Slovan Bratislava's 16th consecutive in the top flight of Slovak football. Slovan successfully retained their league title, winning a record-breaking fourth title in a row and 12th overall since the competition was established in 1993. However, they were not successful in defending their Slovak Cup title, after losing in the final. The season covers the period from 1 June 2021 to 31 May 2022.