The 2016–17 USC Upstate Spartans men's basketball team represented the University of South Carolina Upstate during the 2016–17 NCAA Division I men's basketball season. The Spartans, led by 15th-year head coach Eddie Payne, played their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Atlantic Sun Conference. They finished the season 17–16, 7–7 in ASUN play to finish in a tie for fourth place. They lost in the quarterfinals of the to Kennesaw State. They were invited to the CollegeInsider.com Tournament where they lost in the first round to Furman.