The 2016–17 DePaul Blue Demons women's basketball team represented DePaul University during the 2016–17 NCAA Division I women's basketball season. The Blue Demons, led by 31st year head coach Doug Bruno, played their home games at the McGrath–Phillips Arena as members of the Big East Conference. They finished the season 27–8, 16–2 in Big East play to win the Big East regular season title. They advanced to the championship game of the Big East women's tournament where they lost to Marquette. They received an at-large bid to the NCAA women's tournament where they defeated Northern Iowa in the first round before losing to Mississippi State in the second round.