The 2015–16 DePaul Blue Demons women's basketball team will represent DePaul University during the 2015–16 NCAA Division I women's basketball season. The Blue Demons, led by thirtieth year head coach Doug Bruno, play their home games at the McGrath-Phillips Arena. They were members of the new Big East Conference. They finished the season 27–9, 16–2 in Big East play to win the Big East regular season title. They advanced to the semifinals of the Big East women's tournament where they lost to St. John's. They received an at-large bid to the NCAA women's basketball tournament where they defeated James Madison in the first round, Louisville in the second round before losing to Oregon State in the sweet sixteen.