The 2010 Guia Race of Macau (formally the 2010 Guia Race of Macau, presented by Sociedade de Jogos de Macau) was the eleventh and final round of the 2010 World Touring Car Championship season and the sixth running of the Guia Race of Macau as a World Touring Car Championship round. It was held at the Guia Circuit on the streets of Macau on 21 November 2010. The race was part of the Macau Grand Prix weekend, headlined by the 2010 Macau Grand Prix Formula Three.