The 2010–11 Macedonian First League was the 19th season of the Macedonian First Football League, the highest football league of Macedonia. It began on 31 July 2010 and ended on 28 May 2011. Renova were the defending champions having won their first Macedonian championship last season. The competition was won by Shkëndija, who earned their first overall Macedonian title. FK Skopje and Pelister were relegated to the Second League. Vardar were spared from relegation because of fusion with Miravci.