The 2008 Atlético Nacional season was the club's 61st season since being founded in 1948. Nacional played in the 2008 Copa Libertadores since they won the Copa Mustang consecutively in the previous season, making them the first team in Colombia to achieve this goal since the introduction of the new Copa Mustang format. Oscar Quintabani was the club's manager for the second year in a row. The team roster was almost the same as last year's.