The 2006–07 Quaid-e-Azam Trophy was one of three first-class domestic cricket competitions that were held in Pakistan during the 2006–07 season. The Quaid-e-Azam Trophy was contested by thirteen teams representing regional associations; it was preceded in the schedule by the Patron's Trophy (Grade-I), contested by nine departmental teams, and followed later in the season by the Pentangular Cup, which unlike the previous year did not involve teams from the Quaid-e-Azam Trophy.