The 2000 USC Trojans football team represented the University of Southern California (USC) in the 2000 NCAA Division I-A football season. In their third and final year under head coach Paul Hackett, the Trojans compiled a 5-7 record (2–6 against conference opponents), finished in a three-way tie for last place in the Pacific-10 Conference (Pac-10), and were outscored by their opponents by a combined total of 337 to 309.