The 1959 USC Trojans football team represented the University of Southern California (USC) in the 1959 NCAA University Division football season. In their third year under head coach Don Clark, the Trojans compiled an 8–2 record (3–1 against conference opponents), finished in a tie for the Athletic Association of Western Universities championship, and outscored their opponents by a combined total of 195 to 90. Total attendance for all 10 games was 453,865.