The 1943 Tulane Green Wave football team represented Tulane University as a member of the Southeastern Conference (SEC) during the 1943 college football season. Led by second-year head coach Claude Simons Jr., the Green Wave played their home games at Tulane Stadium in New Orleans. Tulane finished the season with an overall record of 3–3 and a mark of 1–1 in conference play, tying for second in the SEC.