The 1925 Missouri Tigers football team was an American football team that represented the University of Missouri in the Missouri Valley Conference (MVC) during the 1925 college football season. The team compiled a 6–1–1 record (5–1 against Missouri Valley opponents), won the Missouri Valley championship, and outscored all opponents by a combined total of 110 to 44. The team was ranked No. 5 in the nation in the Dickinson System ratings released in January 1926. Gwinn Henry was the head coach for the third of nine seasons.