José Guillermo Santiago Guzmán (September 4, 1928 – October 9, 2018), better known by the nickname "Pantalones", was a Puerto Rican professional baseball pitcher who played in Major League Baseball between 1954 and 1956 for the Cleveland Indians (1954–1955) and Kansas City Athletics (1956). In the Negro leagues, he played for the New York Cubans from 1947 to 1948.