State Route 208 (SR 208) is a primary state highway in the U.S. state of Virginia. The state highway runs 47.35 miles (76.20 km) from U.S. Route 250 (US 250) at east to US 1 and US 1 Business at Four Mile Fork. SR 208 is a major southwest–northeast highway through Louisa and Spotsylvania counties. The state highway connects the counties' respective seats of Louisa and Spotsylvania Courthouse, where the old route of the highway is , with each other and with Fredericksburg near the highway's eastern terminus. SR 208 also has a direct connection with Interstate 64 (I-64) at Ferncliff and an indirect connection to I-95 near Fredericksburg.