State Road 250 (SR 250) in the U.S. State of Indiana is a secondary route that runs from U.S. Route 50 (US 50) in Brownstown eastward toward the Ohio River at State Road 156 (SR 156) in Patriot in southeast Indiana. Towns include Uniontown, Paris Crossing, Canaan, and East Enterprise. SR 250 is split in two north of Madison due to the Big Oaks National Wildlife Refuge (formerly the Jefferson Proving Ground).