The 2022 George Mason Patriots baseball team represented George Mason University during the 2022 NCAA Division I baseball season. The Patriots played their home games at Spuhler Field as a member of the Atlantic 10 Conference. They were led by head coach Bill Brown, in his 41st season at Mason. George Mason finished the season with a 22–33 record and a 13–11 record in Atlantic 10 play. They earned a berth into the 2022 Atlantic 10 Conference baseball tournament, where they were eliminated in game 8 by Richmond.