About: Dehydronorketamine

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Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA receptor (Ki = 38.95 μM for (S)-(+)-DH

Attributes	Values
rdf:type	Thing dul:ChemicalObject chemical substance Drug chemical compound drug
rdfs:label	Dehydronorketamine (en)
rdfs:comment	Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA receptor (Ki = 38.95 μM for (S)-(+)-DH (en)
foaf:depiction
dcterms:subject	Amines Chloroarenes Cyclohexenes Enones Human drug metabolites Nicotinic antagonists
Wikipage page ID	46936167 (xsd:integer)
Wikipage revision ID	1057373142 (xsd:integer)
Link from a Wikipage to another Wikipage	Metabolite Hydroxynorketamine Dehydrogenation Amines Chloroarenes Cyclohexenes Enones Human drug metabolites Nicotinic antagonists Antidepressant Drug test Alpha-3 beta-4 nicotinic receptor Alpha-7 nicotinic receptor Esketamine Norketamine dbr:Arketamine Ketamine IC50 NMDA receptor Forced swim test Negative allosteric modulator
sameAs	Dehydronorketamine Dehydronorketamine Dehydronorketamine Dehydronorketamine
dbp:wikiPageUsesTemplate	dbt:Drugbox dbt:Nervous-system-drug-stub dbt:Reflist dbt:Fdacite dbt:Nicotinic_acetylcholine_receptor_modulators
thumbnail	wiki-commons:Special:FilePath/5,6-Dehydronorketamine.svg?width=300
ATC prefix	None (en)
c	12 (xsd:integer)
CAS number	57683 (xsd:integer)
ChemSpiderID	142954 (xsd:integer)
Cl	1 (xsd:integer)
H	12 (xsd:integer)
IUPAC name	6 (xsd:integer)
n	1 (xsd:integer)
O	1 (xsd:integer)
PubChem	162835 (xsd:integer)
SMILES	C1CCN (en)
StdInChI	1 (xsd:integer)
StdInChIKey	BXBPJMHHWPXBJL-UHFFFAOYSA-N (en)
UNII	J5442FVV58 (en)
has abstract	Dehydronorketamine (DHNK), or 5,6-dehydronorketamine, is a minor metabolite of ketamine which is formed by dehydrogenation of its metabolite norketamine. Though originally considered to be inactive, DHNK has been found to act as a potent and selective negative allosteric modulator of the α7-nicotinic acetylcholine receptor (IC50 = 55 nM). For this reason, similarly to hydroxynorketamine (HNK), it has been hypothesized that DHNK may have the capacity to produce rapid antidepressant effects. However, unlike ketamine, norketamine, and HNK, DHNK has been found to be inactive in the forced swim test (FST) in mice at doses up to 50 mg/kg. DHNK is inactive at the α3β4-nicotinic acetylcholine receptor (IC50 > 100 μM) and is only very weakly active at the NMDA receptor (Ki = 38.95 μM for (S)-(+)-DHNK). It can be detected 7–10 days after a modest dose of ketamine, and because of this, is useful in drug detection assays. (en)
gold:hypernym	Metabolite
prov:wasDerivedFrom	wikipedia-en:Dehydronorketamine?oldid=1057373142&ns=0
page length (characters) of wiki page	5649 (xsd:nonNegativeInteger)
CAS number	57683-62-2
FDA UNII code	J5442FVV58
PubChem	162835
foaf:isPrimaryTopicOf	wikipedia-en:Dehydronorketamine
is Link from a Wikipage to another Wikipage of	Hydroxynorketamine C12H12ClNO Alpha-7 nicotinic receptor Norketamine Ketamine DHNK 5,6-Dehydronorketamine 5,6-dehydronorketamine
is Wikipage redirect of	C12H12ClNO DHNK 5,6-Dehydronorketamine 5,6-dehydronorketamine
is foaf:primaryTopic of	wikipedia-en:Dehydronorketamine

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