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Statements

Subject Item
dbr:Sarecycline
rdf:type
dbo:Drug n11:ChemicalObject dbo:ChemicalSubstance owl:Thing wikidata:Q8386
rdfs:label
Сарециклин Sarecycline
rdfs:comment
Сарециклин — антибиотик группы тетрациклинов узкого спектра действия для лечения акне. Одобрен для применения: США (2018). Sarecycline is a narrow-spectrum tetracycline-derived antibiotic. It is specifically designed for the treatment of acne, and was approved by the FDA in October 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older. Two randomized and well-controlled clinical trials reported efficacy data on both facial and truncal acne (back and chest). Efficacy was assessed in a total of 2002 subjects 9 years of age and older. Unlike other tetracycline-class antibiotics, sarecycline has a long C7 moiety that extends into and directly interact with the bacterial messenger RNA (mRNA). The spectrum of activity is limited to clinically relevant Gram-positive bacteria, mainly Cutibacterium acnes, with little or no activity against Gr
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n10:Sarecycline.svg
dcterms:subject
dbc:Tetracycline_antibiotics
dbo:wikiPageID
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dbo:wikiPageRevisionID
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dbo:wikiPageWikiLink
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owl:sameAs
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dbo:thumbnail
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dbp:atcSuffix
AA14
dbp:atcPrefix
J01
dbp:c
24
dbp:casNumber
1035654
dbp:chembl
2364632
dbp:chemspiderid
28540486
dbp:drugbank
DB12035 DBSALT002125
dbp:h
29
dbp:index2Label
as HCl
dbp:iupacName
-4
dbp:kegg
D10667 D10666
dbp:legalUs
Rx-only
dbp:medlineplus
a618068
dbp:n
3
dbp:o
8
dbp:pubchem
71296095 54681908
dbp:smiles
CN[C@H]1[C@@H]2C[C@@H]3CC4=CCNOC
dbp:synonyms
P-005672
dbp:tradename
Seysara
dbp:unii
94
dbo:abstract
Сарециклин — антибиотик группы тетрациклинов узкого спектра действия для лечения акне. Одобрен для применения: США (2018). Sarecycline is a narrow-spectrum tetracycline-derived antibiotic. It is specifically designed for the treatment of acne, and was approved by the FDA in October 2018 for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients 9 years of age and older. Two randomized and well-controlled clinical trials reported efficacy data on both facial and truncal acne (back and chest). Efficacy was assessed in a total of 2002 subjects 9 years of age and older. Unlike other tetracycline-class antibiotics, sarecycline has a long C7 moiety that extends into and directly interact with the bacterial messenger RNA (mRNA). The spectrum of activity is limited to clinically relevant Gram-positive bacteria, mainly Cutibacterium acnes, with little or no activity against Gram-negative bacterial microflora commonly found in the human gastrointestinal tract. Sarecycline has not been tested in spirochetes.
dbp:dailymedid
Sarecycline
dbp:pdbLigand
V7A
dbp:pronounce
sar"e sye' kleen
prov:wasDerivedFrom
wikipedia-en:Sarecycline?oldid=1090379538&ns=0
dbo:wikiPageLength
6157
dbo:alternativeName
Seysara
dbo:casNumber
1035654-66-0
dbo:chEMBL
2364632
dbo:drugbank
DBSALT002125 DB12035
dbo:fdaUniiCode
94O110CX2E
dbo:kegg
D10667 D10666
dbo:medlinePlus
a618068
dbo:pubchem
54681908
foaf:isPrimaryTopicOf
wikipedia-en:Sarecycline
Subject Item
dbr:Antimicrobial_spectrum
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dbr:Sarecycline
Subject Item
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Subject Item
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Subject Item
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dbr:Sarecycline
Subject Item
dbr:Acne
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dbr:Sarecycline
Subject Item
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dbr:Sarecycline
Subject Item
dbr:Omadacycline
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dbr:Sarecycline
Subject Item
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Subject Item
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