Mary Frances Tarlton "Sissy" Farenthold (October 2, 1926 – September 26, 2021) was an American politician, attorney, activist, and educator. She was best known for her two campaigns for governor of Texas in 1972 and 1974, and for being placed in nomination for vice president of the United States, finishing second at the 1972 Democratic National Convention. She was elected as the first chair of the National Women's Political Caucus in 1973.