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- EML4-ALK positive lung cancer is a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein the echinoderm microtubule-associated protein-like 4 (EML4) gene is fused to the anaplastic lymphoma kinase (ALK) gene. This abnormal gene fusion leads to the production of a protein that appears, in many cases, to promote and maintain the malignant behavior of the cancer cells. The transforming EML4-ALK fusion gene was first reported in non-small cell lung carcinoma (NSCLC) in 2007. (en)
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- 8459 (xsd:nonNegativeInteger)
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- Micrograph showing ALK positive lung adenocarcinoma. H&E stain. (en)
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- EML4-ALK positive lung cancer is a primary malignant lung tumor whose cells contain a characteristic abnormal configuration of DNA wherein the echinoderm microtubule-associated protein-like 4 (EML4) gene is fused to the anaplastic lymphoma kinase (ALK) gene. This abnormal gene fusion leads to the production of a protein that appears, in many cases, to promote and maintain the malignant behavior of the cancer cells. The transforming EML4-ALK fusion gene was first reported in non-small cell lung carcinoma (NSCLC) in 2007. (en)
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- EML4-ALK positive lung cancer (en)
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