45th Regiment Massachusetts Volunteer Infantry was an infantry regiment in the Union army during the American Civil War. The regiment trained at Camp Meigs in Readville, Massachusetts before traveling to North Carolina, where they fought in the Battle of Kinston in December 1862, and in skirmishes in and around New Bern, North Carolina in the spring of 1863. They suffered heavy casualties in battle and due to fever. In June they returned to Boston, where they patrolled the streets to quell any draft riots, and were discharged on July 21. They were commanded by Colonel Charles R. Codman (1829-1918).