U.S. Route 278 (US 278) is a parallel route of US 78. It currently runs for 1,074 miles (1,728 km) from Hilton Head Island, South Carolina, to Wickes, Arkansas at US 71/US 59, passing through five states in the process. Landmarks along its route include the Department of Energy's Savannah River Site in South Carolina and the Tennessee-Tombigbee Waterway in eastern Mississippi. There are several universities located along the highway including Georgia State University, the University of Mississippi, and the University of Arkansas at Monticello.