The Tonawanda Indian Reservation (Seneca: Ta:nöwöde') is an Indian reservation of the Tonawanda Seneca Nation located in western New York, United States. The band is a federally recognized tribe and, in the 2010 census, had 693 people living on the reservation. The reservation lies mostly in Genesee County, extending into Erie and Niagara counties. It is bordered by the Towns of Alabama, Pembroke, Newstead, and Royalton.