The men's 50 metre freestyle event at the 2010 Asian Games took place on 15 November 2010 at Guangzhou Aoti Aquatics Centre. There were 44 competitors from 31 countries who took part in this event. Six heats were held, with most containing the maximum number of swimmers (eight). The heat in which a swimmer competed did not formally matter for advancement, as the swimmers with the top eight times from the entire field qualified for the finals. Lü Zhiwu from China won the gold medal with 22.37 seconds, two Japanese swimmers Masayuki Kishida and won the silver and bronze medal respectively.