Stormie Dawn Jones (May 30, 1977 – November 11, 1990) was the world's first recipient of a successful simultaneous heart and liver organ transplant. On February 14, 1984, under the direction of Dr. Thomas E. Starzl, Drs. Byers W. Shaw Jr. and replaced the six-year-old's heart and liver at the Children's Hospital of Pittsburgh in Pittsburgh, Pennsylvania. Stormie had a condition which raised her blood cholesterol to 10 times normal levels. The condition, a severe form of familial hypercholesterolemia,and the resultant high levels of low density lipoprotein that damaged her organs, gave her two heart attacks when she was six years old. The case showed that the liver controls blood cholesterol and that high cholesterol is controllable, and was part of the research on cholesterol and the live
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| - Stormie Dawn Jones (May 30, 1977 – November 11, 1990) was the world's first recipient of a successful simultaneous heart and liver organ transplant. On February 14, 1984, under the direction of Dr. Thomas E. Starzl, Drs. Byers W. Shaw Jr. and replaced the six-year-old's heart and liver at the Children's Hospital of Pittsburgh in Pittsburgh, Pennsylvania. Stormie had a condition which raised her blood cholesterol to 10 times normal levels. The condition, a severe form of familial hypercholesterolemia,and the resultant high levels of low density lipoprotein that damaged her organs, gave her two heart attacks when she was six years old. The case showed that the liver controls blood cholesterol and that high cholesterol is controllable, and was part of the research on cholesterol and the live (en)
- Het zesjarige meisje Stormie Jones (30 mei 1977 - 11 november 1990) uit Texas was de eerste persoon die een geslaagde gecombineerde hart-levertransplantatie onderging. De chirurgie werd uitgevoerd in het kinderziekenhuis van Pittsburgh door Dr. Starzl en zijn team op 14 februari 1984. Deze operatie was belangrijk omdat het bewijs geleverd zou worden dat de lever de cholesterol controleert die in het menselijk lichaam wordt gevonden. Stormie overleed op 11 november 1990. Haar overlijden was gerelateerd aan het feit dat haar lichaam het donorhart afstootte. (nl)
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| - Pittsburgh, Pennsylvania, U.S. (en)
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| - Fort Worth, Texas, U.S. (en)
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| - Stormie Jones, the world’s first heart-liver transplant recipient, initially was treated at UT Southwestern. (en)
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| - Stormie Dawn Jones (May 30, 1977 – November 11, 1990) was the world's first recipient of a successful simultaneous heart and liver organ transplant. On February 14, 1984, under the direction of Dr. Thomas E. Starzl, Drs. Byers W. Shaw Jr. and replaced the six-year-old's heart and liver at the Children's Hospital of Pittsburgh in Pittsburgh, Pennsylvania. Stormie had a condition which raised her blood cholesterol to 10 times normal levels. The condition, a severe form of familial hypercholesterolemia,and the resultant high levels of low density lipoprotein that damaged her organs, gave her two heart attacks when she was six years old. The case showed that the liver controls blood cholesterol and that high cholesterol is controllable, and was part of the research on cholesterol and the liver that won Joseph L. Goldstein and Michael S. Brown the Nobel prize in medicine in 1985. Stormie died on November 11, 1990. Her death was related to rejection of the heart transplant she had received in 1984. There were very specific reasons for performing a combined heart and liver transplant in this young girl. Due to her inherited condition, Stormie's liver was unable to remove cholesterol, i.e. LDL-cholesterol, from her bloodstream. As a result, her LDL-cholesterol levels became very high and caused her two heart attacks by age six. On the other hand, the transplanted liver, being normal and healthy, was able to clear the LDL-cholesterol from her blood. Indeed, after the transplant, Stormie's LDL-cholesterol declined by 81%—from an astounding 988 to a near-normal 184 mg per deciliter. Since she was going to require lifelong immunosuppressant therapy anyway to prevent rejection of her transplanted liver, and since her heart had been severely damaged by her previous heart attacks, it was decided to also perform a heart transplant. (en)
- Het zesjarige meisje Stormie Jones (30 mei 1977 - 11 november 1990) uit Texas was de eerste persoon die een geslaagde gecombineerde hart-levertransplantatie onderging. De chirurgie werd uitgevoerd in het kinderziekenhuis van Pittsburgh door Dr. Starzl en zijn team op 14 februari 1984. Deze operatie was belangrijk omdat het bewijs geleverd zou worden dat de lever de cholesterol controleert die in het menselijk lichaam wordt gevonden. Stormie overleed op 11 november 1990. Haar overlijden was gerelateerd aan het feit dat haar lichaam het donorhart afstootte. Dr. Michael S. Brown en Dr. Joseph L. Goldstein ontvingen in 1985 de Nobelprijs voor geneeskunde door hun onderzoek op Stormie Jones. Ze kregen deze prijs voor het beschrijven van de regulatie van het cholesterolmetabolisme. (nl)
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