Mesenchymal stem cells (MSCs) are multipotent cells found in multiple human adult tissues including bone marrow, synovial tissues, and adipose tissues. Since they are derived from the mesoderm, they have been shown to differentiate into bone, cartilage, muscle, and adipose tissue. MSCs from embryonic sources have shown promise scientifically while creating significant controversy. As a result, many researchers have focused on adult stem cells, or stem cells isolated from adult humans that can be transplanted into damaged tissue.
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| - Trasplantament de cèl·lules mare per a reparació del cartílag articular (ca)
- Stem cell transplantation for articular cartilage repair (en)
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| - Les (MSC) són cèl·lules pluripotencials que es troben en múltiples teixits adults humans, incloent la medul·la òssia, els teixits sinovials i els teixits adiposos. Com que es deriven del mesoderm, s'ha demostrat que es diferencien en teixit ossi, cartílaginós, muscular i adipós. Els MSC procedents de fonts embrionàries han demostrat ser prometedors científicament, tot creant una controvèrsia significativa. Com a resultat, molts investigadors s'han centrat en cèl·lules mare adultes, o cèl·lules mare aïllades d'humans adults que es poden trasplantar a teixits danyats. (ca)
- Mesenchymal stem cells (MSCs) are multipotent cells found in multiple human adult tissues including bone marrow, synovial tissues, and adipose tissues. Since they are derived from the mesoderm, they have been shown to differentiate into bone, cartilage, muscle, and adipose tissue. MSCs from embryonic sources have shown promise scientifically while creating significant controversy. As a result, many researchers have focused on adult stem cells, or stem cells isolated from adult humans that can be transplanted into damaged tissue. (en)
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| - Les (MSC) són cèl·lules pluripotencials que es troben en múltiples teixits adults humans, incloent la medul·la òssia, els teixits sinovials i els teixits adiposos. Com que es deriven del mesoderm, s'ha demostrat que es diferencien en teixit ossi, cartílaginós, muscular i adipós. Els MSC procedents de fonts embrionàries han demostrat ser prometedors científicament, tot creant una controvèrsia significativa. Com a resultat, molts investigadors s'han centrat en cèl·lules mare adultes, o cèl·lules mare aïllades d'humans adults que es poden trasplantar a teixits danyats. A causa de les seves capacitats pluripotencials, els llinatges de les cèl·lules mare mesenquimàtiques s'han utilitzat amb èxit en models animals per regenerar el cartílag articular i en models humans per regenerar ossos. Les investigacions mostren que el cartílag articular es pot reparar mitjançant la introducció percutània de cèl·lules mare mesenquimàtiques, procedents de l'aspiració de medul·la òssia. (ca)
- Mesenchymal stem cells (MSCs) are multipotent cells found in multiple human adult tissues including bone marrow, synovial tissues, and adipose tissues. Since they are derived from the mesoderm, they have been shown to differentiate into bone, cartilage, muscle, and adipose tissue. MSCs from embryonic sources have shown promise scientifically while creating significant controversy. As a result, many researchers have focused on adult stem cells, or stem cells isolated from adult humans that can be transplanted into damaged tissue. Because of their multi-potent capabilities, mesenchymal stem cell (MSC) lineages have been used successfully in animal models to regenerate articular cartilage and in human models to regenerate bone. Recent research demonstrates that articular cartilage may be able to be repaired via percutaneous introduction of mesenchymal stem cells (MSC's). Stem cells as a concept originated as a theory in the 19th century to potentially allow certain tissues to self-renew. There are five types of stem cells and MSC's are multi-potent meaning they are cells that have the ability to develop into more than one type of specialized cell. Mesenchymal stem cells were originally discovered and studied as fibroblast-colony forming cells in guinea-pig bone marrow and spleen cells by Friedenstein in the 1970s. This study proved that the colony-forming units of bone marrow derived stem cells were able to form cartilage once they were transplanted in a diffusion chamber. The results of this study set the stage for future research by indicating the differentiation capacity of MSC's. (en)
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