Sir William Yorke, 1st Baronet PC (c. 1700 – 30 September 1776) was an English-born politician and judge in eighteenth-century Ireland, who held office as Chief Justice of the Irish Common Pleas and as Chancellor of the Exchequer of Ireland. His last years were plagued by ill health: he suffered agonies from a kidney stone, and his death was caused by an accidental drug overdose, which he took in an effort to relieve the chronic pain.