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About: dbr:Pyocyanin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatPigments, within Data Space : dbpedia.org:8891 associated with source document(s)

Type: Thingdul:ChemicalObjectchemical substanceChemical compoundyago:Abstraction100002137yago:Chemical114806838yago:ColoringMaterial114984973yago:Compound114818238yago:Ketone114926294yago:Material114580897yago:Matter100020827yago:OrganicCompound114727670yago:Part113809207yago:PhysicalEntity100001930yago:Pigment114989820yago:Relation100031921yago:WikicatKetoneschemical compoundproteinyago:Substance100019613yago:WikicatPigments New Facet based on Instances of this Class

Pyocyanin (PCN−) is one of the many toxic compounds produced and secreted by the Gram negative bacterium Pseudomonas aeruginosa. Pyocyanin is a blue secondary metabolite, turning red below pH 4.9, with the ability to oxidise and reduce other molecules and therefore kill microbes competing against P. aeruginosa as well as mammalian cells of the lungs which P. aeruginosa has infected during cystic fibrosis. Since pyocyanin is a zwitterion at blood pH, it is easily able to cross the cell membrane. There are three different states in which pyocyanin can exist: oxidized (blue), monovalently reduced (colourless) or divalently reduced (red). Mitochondria play an important role in the cycling of pyocyanin between its redox states. Due to its redox-active properties, pyocyanin generates reactive ox