New York State Route 145 (NY 145) is a state highway in eastern New York in the United States. The highway extends for 47 miles (76 km) from NY 23 in the Greene County town of Cairo to U.S. Route 20 (US 20) in the Schoharie County town of Sharon. Along the way, NY 145 intersects NY 30 in Middleburgh and Interstate 88 (I-88) east of Cobleskill. NY 145 is a two-lane highway its entire length, with a passing lane on hills leaving Middleburgh in both directions. The route follows parts of the Susquehannah Turnpike from Cairo through East Durham and west.